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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Aug 1;1843(11):2719–2729. doi: 10.1016/j.bbamcr.2014.07.014

Figure 10. Model of the Regulation of Cofilin Phosphorylation.

Figure 10

A: Cofilin, causing the inactivation of the protein leading to accumulation of F-actin. B: Aur-A phosphorylates LIMK1 at S307 priming it for full activation by phosphorylation at T508. C: Interaction with LIMK1 allows the activation of Aur-A through autophosphorylation at T288. D: LIMK1 phosphorylates Cofilin and inactivates it. E: Overexpression of Aur-A up regulates SSH-1. F: SSH-1 activates Cofilin in late mitosis through dephosphorylation leading to the depolymerization of F-actin. G: SSH-1 inactivates LIMK1 in late mitosis by dephosphorylation at T508.