Table 2.
Percent difference in IGF-axis protein levels per unit increase (or per level increase) in sociodemographic/lifestyle characteristics using linear regression models (n=558)
| Characteristic | Total IGF-I, % | Free IGF-I, % | IGFBP-1, % | IGFBP-2, % | IGFBP-3, % |
|---|---|---|---|---|---|
| Age | |||||
| Model 1 | −1.4 (−1.7 to −1.0) | −1.8 (−2.7 to −1.0) | 1.6 (0.5 to 2.6) | 0.9 (0.2 to 1.6) | −0.2 (−0.4 to 0.1) |
| Model 2 | −0.8 (−1.2 to −0.3) | −0.2 (−1.3 to 0.9) | 0.1 (−0.9 to 1.0) | 1.3 (0.5 to 2.2) | −0.2 (−0.5 to 0.1) |
| Model 3 | −0.8 (−1.3 to −0.4) | −0.3 (−1.4 to 0.8) | −0.2 (−1.1 to 0.8) | 1.5 (0.7 to 2.2) | −0.3 (−0.6 to 0) |
| Caucasian | |||||
| Model 1 | 4.9 (−18.0 to 34.2) | −35.5 (−57.1 to −3.0) | 43.1 (−10.0 to 127.6) | 43.3 (2.0 to 101.2) | 21.2 (−5.0 to 54.6) |
| Model 2 | 5.8 (−15.6 to 32.7) | −31.5 (−51.9 to −2.4) | 12.4 (−26.2 to 71.2) | 30.3 (−6.1 to 80.8) | 22.7 (−3.9 to 56.6) |
| Model 3 | 0.9 (−15.7 to 20.4) | −35.4 (−53.7 to −10.0) | 18.8 (−17.7 to 71.5) | 23.6 (−9.4 to 68.7) | 21.3 (−1.4 to 49.2) |
| Postmenopausal | |||||
| Model 1 | −14.2 (−20.9 to −7.0) | −33.5 (−44.5 to −20.4) | 42.6 (14.8 to 77.1) | −10.7 (−23.8 to 4.6) | 1.2 (−4.2 to 6.9) |
| Model 2 | −5.9 (−13.3 to 2.2) | −16.5 (−30.3 to 0) | 10.7 (−8.1 to 33.3) | −5.8 (−18.1 to 8.2) | 5.2 (−0.7 to 11.4) |
| Model 3 | −4.5 (−11.5 to 3.1) | −15.2 (−28.9 to 1.3) | 10.5 (−6.5 to 30.5) | −2.5 (−13.4 to 9.9) | 5.7 (0 to 11.8) |
| Current HT use | |||||
| Model 1 | −21.4 (−25.8 to −16.9) | −45.1 (−52.5 to −36.6) | 82.7 (60.6 to 107.7) | −16.5 (−25.4 to −6.5) | −7.8 (−11.5 to −4.0) |
| Model 2 | −20.7 (−25.3 to −15.8) | −42.1 (−50.3 to −32.6) | 58.1 (40.8 to 77.6) | −22.4 (−30.4 to −13.4) | −8.2 (−12.1 to −4.0) |
| Model 3 | −16.9 (−21.6 to −12.0) | −34.7 (−44.1 to −23.7) | 40.9 (25.2 to 58.7) | −23.2 (−30.4 to −15.2) | −7.5 (−11.5 to −3.3) |
| Current Smoking | |||||
| Model 1 | 6.6 (−1.4 to 15.2) | 30.1 (8.5 to 55.9) | −10.5 (−26.3 to 8.6) | 15.2 (0.1 to 32.6) | 0.3 (−5.0 to 5.9) |
| Model 2 | 5.8 (−1.5 to 13.6) | 26.5 (7.8 to 48.5) | −6.3 (−19.1 to 8.6) | 14.8 (2.5 to 28.7) | −0.2 (−5.4 to 5.4) |
| Model 3 | 5.6 (−2.4 to 14.2) | 18.4 (−0.9 to 41.5) | 11.0 (−4.8 to 29.5) | 25.4 (13.1 to 39.1) | 0.3 (−5.3 to 6.3) |
| BMI | |||||
| Model 1 | 0.1 (−0.6 to 0.7) | 1.7 (0.2 to 3.1) | −9.6 (−10.9 to −8.2) | −5.7 (−6.7 to −4.8) | 0.6 (0.1 to 1.0) |
| Model 2 | −0.2 (−0.8 to 0.4) | 0.8 (−0.5 to 2.1) | −8.8 (−10.1 to −7.5) | −6.1 (−7.1 to −5.0) | 0.5 (0.1 to 0.9) |
| Model 3 | −0.6 (−1.3 to 0.2) | 0.2 (−1.6 to 2.1) | −4.8 (−6.5 to −3.1) | −0.9 (−2.3 to 0.6) | −0.1 (−0.7 to 0.6) |
| Physical Activity | |||||
| Model 1 | 0.1 (0 to 0.3) | 0 (−0.4 to 0.4) | 0.6 (0.2 to 1.0) | 0.3 (0 to 0.5) | 0 (−0.1 to 0.1) |
| Model 2 | 0.1 (0 to 0.3) | 0.1 (−0.3 to 0.4) | 0.3 (0 to 0.7) | 0.1 (−0.1 to 0.4) | 0 (−0.1 to 0.1) |
| Model 3 | 0 (−0.1 to 0.2) | 0 (−0.4 to 0.3) | 0.2 (−0.1 to 0.5) | −0.1 (−0.3 to 0.1) | 0 (−0.1 to 0.1) |
Hormone therapy (HT) (versus past/never), body mass index (BMI), Model 1 adjusted for age and race/ethnicity; Model 2 adjusted for Model 1 + menopausal status (pre/post), current HT use (versus past/never), current smoking (versus past/never), BMI, and physical activity (continuous, METs/wk); Model 3: Model 2 + CRP, Adiponectin, Resistin, Leptin, sOb-R, Insulin, HbA1C%, IL-18) +energy (kcal) + alcohol %kcal + dairy protein %kcal + fat %kcal (trans fat, saturated fat, polyunsaturated fat, monounsaturated fat)