Table 1.
Demographic and clinical characteristics of sequenced participants and family members
| Sequenced | Relatives | Controls | ||||
|---|---|---|---|---|---|---|
| Characteristics | n | Mean | n | Mean | n | Mean |
| Number of subjects sequenced/genotyped1 | 195 | 318 | 498 | |||
| Number of families2 | 194 | 56 | ||||
| Affection status | ||||||
| Affected | 183 | 94.0% | 104 | 33.0% | ||
| Unaffected | 10 | 5.0% | 197 | 62.0% | 498 | 100.0% |
| Unknown | 2 | 1.0% | 17 | 5.0% | ||
| Proportion of females | 64/131 | 67.2% | 142/176 | 55.30% | 152/346 | 69.5 |
| Age (year) | ||||||
| Age at onset of affected | 56.9 (SD = 7.29) | 68.5 (SD = 12.64) | ||||
| Age at last examination of unaffected | 66.7 (SD = 5.66) | 58.8 (SD = 11.31) | 79.1 (SD= 6.2) | |||
| Range of age at onset | 40–73 | 44–98 | ||||
| Education (year) | 8.4 (SD = 5.45) | 90 (SD =5.79 ) | 7.6 (SD = 4.35) | |||
| Range of education | 0–20 | 0–22 | 0–20 | |||
| Residency | ||||||
| Puerto Rico | 67 | 34.4% | 147 | 46.2% | 69 | 13.9% |
| Dominican Republic | 127 | 65.1% | 165 | 51.9% | 210 | 42.2% |
| USA | 1 | 0.5% | 0 | 0.0% | 10 | 2.0% |
| Other Hispanics3 | 0 | 0.0% | 0 | 0.0% | 132 | 26.5% |
| Unknown/others4 | 0 | 0.0% | 6 | 1.9% | 77 | 15.5% |
| APOE allele frequencies | ||||||
| E4 | 32.1% | 24.1% | 13.0% | |||
| E3 | 64.4% | 70.9% | 79.2% | |||
| E2 | 3.6% | 5.0% | 7.8% | |||
1
Three individuals identified from separate sequencing experiments.
2
One family had more than one person sequenced.
3
Self-reported Hispanics but unclear about their nationality and place of birth.
4
Incomplete information.