Table 3.

Joint linkage and association analysis using families and 498 unrelated controls

			P-values (with unrelated controls)
Gene	Variant name	MAF in controls	Linkage1	LD and linkage2
APP	p.Ala344Val	0	0.1195	0.0005
	p.Ser614Gly	0.008	0.4958	0.0107
	p.Val340Met	0	0.5	0.0007
PSEN1	p.Glu318Gly	0.0131	0.3805	6.0E-6
	p.Gly206Ala	0	8.94E-07	<1.0E-24
PSEN2	p.Ala344Val	0.001	0.2717	0.003
	p.Ile235Phe	0	0.5	0.0005
	p.Pro301Ala	0	0.5	0.0017
GRN	p.Cys222Tyr	0	0.5	0.0005
	p.Val519Met	0	0.4915	6.8E-08
MAPT	p.Ile468Thr	0.002	0.3017	0.0054
	p.Ser318Leu	0.0552	0.4893	2.4E-05

LD, linkage disequilibrium; APP, amyloid precursor protein; PSEN1, presenilin 1; PSEN2, presenilin 2; GRN, granulin; MAPT, microtubule-associated protein tau; MAF, minor allele frequency.

¹P-values for linkage analysis.

²P-value for joint linkage and LD.