Table I.
Comparison of baseline demographics, laboratory features, and Doppler studies of patients with non-alcoholic steatohepatitis and controls.
| NASH (n = 50) | Controls (n = 30) | p value | |
|---|---|---|---|
| Age (years) | 42 ± 9 | 41 ± 6 | 0.686 |
| Gender (male/female) | 27/23 | 19/11 | 0.414 |
| BMI (kg/m2) | 30 ± 4 | 28 ± 3 | 0.004 |
| Glucose (mg/dL) | 90 ± 12 | 92 ± 8 | 0.662 |
| Total cholesterol (mg/dL) | 221 ± 36 | 205 ± 38 | 0.065 |
| LDL cholesterol (mg/dL) | 126 ± 27 | 119 ± 39 | 0.359 |
| HDL cholesterol (mg/dL) | 42 ± 6 | 43 ± 7 | 0.782 |
| Triglyceride (mg/dL) | 172 ± 57 | 174 ± 33 | 0.835 |
| Creatinine (mg/dL) | 0.8 ± 0.3 | 0.9 ± 0.3 | 0.325 |
| GGT (U/L) | 55 ± 18 | 36 ± 20 | <0.001 |
| AST (U/L) | 48 ± 10 | 30 ± 6 | <0.001 |
| ALT (U/L) | 61 ± 22 | 45 ± 13 | 0.001 |
| Insulin (µU/mL) | 13 ± 3 | 5 ± 2 | <0.001 |
| HOMA-IR | 3.3 ± 1.5 | 1.5 ± 0.3 | <0.001 |
| Ejection fraction (%) | 65 ± 6 | 66 ± 5 | 0.183 |
| BA baseline diameter (mm) | 40 ± 6 | 39 ± 4 | 0.172 |
| FMD (%) | 4.9 ± 2.8 | 9.3 ± 4.4 | <0.001 |
| CIMT (mm) | 0.79 ± 0.16 | 0.64 ± 0.11 | <0.001 |
AST = aspartic acid transaminase; ALT = alanine transaminase; BA = brachial artery; BMI = body mass index; CIMT = carotid intima-media thickness; FMD = flow-mediated dilatation; GGT = gamma glutamyl transferase; HDL = high-density lipoprotein; LDL = low-density lipoprotein.