Figure 6. Normalization of p75^NTR levels in mutant KI mice reverses the altered expression of synaptic-related proteins.

Representative Western blots showing (A) total and phospho-CaMKII^Thr286, (B) total and phospho-GluA1^Ser831, (C) BDNF, and (D) CBP and actin as loading control in total hippocampus extracts from WT, p75^+/–, KI, and KI:p75^+/– mice at 6 months of age (n = 6–7 per genotype). All histograms represent mean ± SEM. One-way ANOVA with Tukey post hoc comparisons was performed. *P < 0.05 compared with WT mice; ^§P < 0.05 and ^§§P < 0.01 compared with KI mice. pCaMKII^Thr286, phospho–Ca²⁺/calmodulin-dependent protein kinase II at threonine 286; pGluA1^Ser831, phospho–α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit 1 at serine 831; BDNF, brain-derived neurotrophic factor; CBP, CREB-binding protein.