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BFT binds to a specific, but as-yet uncharacterized, CEC receptor, triggering a marked array of CEC signal transduction, E-cadherin cleavage, Wnt signaling, and secretion of proinflammatory cytokines contributing to key aspects of ETBF carcinogenic potential, including increased CEC barrier permeability, mucosal inflammation, CEC proliferation, DNA damage, and enhancement of metastatic potential (see text). PS1, presenilin-1.
