Figure 8. Hemostasis and thrombus formation are impaired in STXBP5-deficient mice.

(A) Tail bleeding times were measured after tail transection from Stxbp5 KO (n = 24) and WT (n = 19) littermates. (B) Thrombus formation in the carotid artery was induced by topical application of 5% FeCl₃, and blood flow was monitored from Stxbp5 KO (n = 10) and WT (n = 9) littermates. (C and D) Chimeric mice (WT BM transplanted into Stxbp5 KO littermates [WT→KO], n = 7; Stxbp5 KO BM transplanted into WT littermates [KO→WT], n = 5) were analyzed using the same assays. Tail bleeding times (C) and the time to blood flow cessation from 5% FeCl₃-induced carotid thrombosis (D) were measured. Each symbol represents an individual mouse; mean ± SEM are noted. P values (log-rank test) are indicated.