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. 2014 Nov 6;11(100):20140774. doi: 10.1098/rsif.2014.0774

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© 2014 The Author(s) Published by the Royal Society. All rights reserved.

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Figure 1. — The diagram for the cancer network including 32 nodes (genes) and 111 edges (66 activation interactions and 45 repression interactions). Red arrows represent activation and blue filled circles represent repression. The network includes mainly three kinds of marker genes: apoptosis (green nodes), cancer marker genes (magenta nodes) and tumour repressor genes (light blue nodes). The cancer marker genes include EGFR for proliferative signal, VEGF for angiogenesis, HGF for metastasis, hTERT for unlimited replication, HIF1 for glycolysis, CDK2 and CDk4 for evading growth suppressors. The solid black links represent the key links found by the global sensitivity analysis, and the octagon shape nodes represent key genes for the transition between normal and cancer states found by global sensitivity analysis. The brown nodes represent other genes.