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. 2014 Nov 6;11(100):20140774. doi: 10.1098/rsif.2014.0774

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© 2014 The Author(s) Published by the Royal Society. All rights reserved.

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Figure 6. — The effects of key parameters (10 repression parameters and 15 activation parameters) on the barrier (U_SN and U_SC) and MFPT (mean first passage time, τ_NC and τ_CN) from Langevin dynamics. Y-axis represents the percentage of barrier or MFPT changed. Here, U_SN represents the potential difference between the saddle point (between normal attractor and cancer attractor) and the local minimum in normal attractor. U_SC represents the potential difference between the saddle point (between normal attractor and cancer attractor) and the local minimum in cancer attractor. τ_NC represents the MFPT from normal attractor to cancer attractor. τ_CN represents the MFPT from the cancer attractor to the normal attractor.