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. 2014 Oct 9;2:184. doi: 10.3389/fpubh.2014.00184

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Copyright © 2014 Neira, Mahmood, Reisen, James and Romoser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell rounding and sloughing (CRS). (A) Anterior midgut section of a specimen of the KNWR strain, 14 days after ingesting a blood meal containing 3-log PFU of WEEV per 0.1 ml blood. Notice how several epithelial cells have sloughed-off into the lumen, and some rounded cells protrude from the tissue. (B) Comparable section of anterior midgut in an uninfected control, where no CRS is observed. FB, Fat body; L, midgut lumen; M, skeletal muscle; ME, midgut epithelium; R, rounded epithelial cell; S, sloughed epithelial cell.