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The DA and DOPAC analyses between day (ZT3) and night (ZT22) in WT and Gnat1−/− mice at 8 weeks of age. (A, C) The DOPAC levels and DOPAC/DA ratios were lower in Gnat1−/− compared to WT retinas at ZT22 (Students t-test, P < 0.01). The WT retinas showed a greater increase in DOPAC levels and DOPAC/DA ratio in the light phase compared to Gnat1−/− retinas. (B) DA levels were similar between day and night in WT and Gnat1−/− mice. Error bars: mean ± SEM.
