Figure 1.

Resveratrol (RES) and curcumin (CUR) enhance insulin secretion in pancreatic β-cells. Mouse β-Min6 cells were treated with (A) RES or (B) CUR for 2 h under low- (1 mmol/l) or high- (25 mmol/l) glucose conditions. Primary human islets (n=2 donors) were incubated with (C) RES or (D) CUR for 2 h under low- (5 mmol/l) or high- (25 mmol/l) glucose conditions. Supernatants from triplicate samples were analyzed for insulin secretion (*P<0.05, **P<0.01, ***P<0.001, and ****P<0.0001). Data are representative of at least three independent experiments.