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. 2014 Oct 9;5:478. doi: 10.3389/fimmu.2014.00478

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Copyright © 2014 Mattila and Thomas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NOS2 is strongly expressed by ciliated pseudostratified columnar epithelial cells in the cynomolgus macaque lung. Formalin-fixed paraffin-embedded lung tissue sections were stained for (A) NOS2 (green) or (B) NOS3 (green) in combination with CD163 (red), a hemoglobin scavenger receptor expressed on macrophages and epithelial cells, and imaged by widefield epifluorescence microscopy. Intense NOS2 expression can be observed in the basal cells underlying the ciliated cells, with less intense staining in the ciliated cells. NOS3 staining is associated with cells in the lamina propria but not ciliated epithelial cells. This staining is characteristic of ciliated epithelia of both uninfected and Mycobacterium tuberculosis-infected macaques (pictured). DAPI-stained nuclei are indicated in blue.