Table 1. Major pathologic Differential Diagnosis of Sarcoidosis at Biopsy.

LUNG	LYMPH NODE	SKIN	LIVER	BONE MARROW	OTHER BIOPSY SITES
Tuberculosis Atypical mycobacteriosis Fungi Pneumocystis carinii Mycoplasma Hypersensitivity pneumonitis Pneumoconiosis: Beryllium (chronic beryllium disease), Titanium, Aluminum Drug reactions Aspiration of foreign materials Wegener’s granulomatosis (Sarcoid-type granulomas are rare) Necrotizing sarcoid granulomatosis (NSG)	Tuberculosis Atypical mycobacteriosis Brucellosis Toxoplasmosis Granulomatous histiocytic necrotizing lymphademitis (Kikuchi’s disease) Cat-scratch disease Sarcoid reaction in regional lymph nodes to carcinoma Hodgkin’s disease Non-Hodgkin’s lymphomas Granulomatous lesions of unknown significance (the GLUS syndrome)	Tuberculosis Atypical mycobacteriosis Fungi Reaction to foreign bodies: beryllium, zirconium, tattooing, paraffin, etc. Rheumatoid nodules	Tuberculosis Brucellosis Schistosomiasis Primary biliary cirrhosis Crohn’s disease Hodgkin’s disease Non-Hodgkin’s lymphomas GLUS syndrome	Tuberculosis Histoplasmosis Infectious mononucleosis Cytomegalovirus Hodgkin’s disease Non-Hodgkin’s lymphomas Drugs GLUS syndrome	Tuberculosis Brucellosis Other infections Crohn’s disease Giant cell myocarditis GLUS syndrome

Adapted from reference [27] and reprinted with permission of the American Thoracic Society. Copyright © 2014 American Thoracic Society.

Official Journal of the American Thoracic Society.