Table 1. Characteristics of NK cell memory in different models Comparison of the four major types of NK cell memory. Lymphopenia-induced memory NK cells are not shown. See text for details.
| Memory type | Liver | CMV | FcεRγ Deficiency | Cytokine-induced |
|---|---|---|---|---|
| Subpopulations | Thy1+CD11b+CD27- Thy1+Ly49C/I+ [78,116] CXCR6+ [78] CD49a+DX5-[79] |
Mouse: Ly49H+ [80] Human: NKG2C+ [86] CD57+ [92] |
CD57dimFcεRγ- [100] | CD25+ [107] |
| Antigen | Haptens or viral antigens [78,117] | m157 [80] | (m157?) | - |
| Proliferation | No [77] | Yes [80] | Unknown | Yes [96] |
| Involved cytokines | IL-12 [106] CXCL16 [78] |
IL-12, IL-15 [82] | IL-12? | IL-12, IL-15, IL-18 [94] |
| Signaling | IL-12R [106] CXCR6 [78] NKG2D [77] |
IL-12R /STAT4 [82] IL-15R CD25 [108] Ly49H/DAP12 [80] DNAM-1 via Fyn, PKC [81] Zbtb32 [84] Bim [85] miR-155 [110] |
IL-12R? | IL-12R /STAT4 IL-15R IL-18R CD25 [107] miR-155 [112] |
| Memory effect | DTH | Enhanced cytotoxicity and IFNγ production | Enhanced IFNγ production and ADCC | Enhanced IFNγ production |
ADCC, antibody-dependent cellular cytotoxicity; DTH, delayed-type-hypersensitivity; IL, IFNΦΦinterferon; interleukin; PKC, protein kinase C; STAT4, signal transducer and activator of transcription 4.