Figure 2.

Dependency on genomic distance for the initial (gray) and the refined (red) interactions. Genomic distance (δ_ij), defined as the distance between pairs of anchors, plotted against the observed average number of interactions. The gray line shows the result after cubic spline smoothing on the original, non-refined dataset. The red line shows the smoothed dependency for the refined dataset, which gives the expected interaction frequencies (λ_ij), as explained in the ‘Materials and Methods’ section. Results for K562 (left) and Mcf7 (right) are shown.