Figure 7.

(a) The phylogenetic tree of the whole exome sequencing results of 30 TCGA breast cancer tumor samples (from 25 patients) and 5 NCI-60 breast cancer cell lines and the proteome-wide functional site analysis. The five breast cancer cell lines from the NCI-60 panel are shaded in green. Branches are colored to visualize the bootstrap value (color from red to yellow represents the corresponding bootstrap value from high to low). Heatmap demonstrates the status of loss of functional sites of each individual sample is overlaid at the tip of the phylogenetic tree branches. From inside to outside of the heatmap contains mutated functional sites from acetylation to ubiquitylation. (b) A hierarchal clustering is performed based on significance of mutational profile on functional site. Underrepresentation is colored in red and overrepresentation is in blue. The darkness of the color in each box reflects the absolute value of –log(P-value). Based on the patterns of –log(P-value), cancer samples/cell lines are clustered into different groups.