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. 2014 Sep 15;42(18):11339–11348. doi: 10.1093/nar/gku791

Figure 5.

Figure 5.

TLE3 hinders the recruitment of ERα, FoxA1 and RNAPII and reduces the acetylation of histones at TFF1 regulatory elements in absence of estrogen. TLE3, ERα, FoxA1 and RNAPII occupancy and H3K27Ac and H4PanAc relative abundance at TFF1 regulatory elements, as described in Figure 2A, measured by ChIP in MCF-7 cells grown in estrogen-free medium and depleted (shTLE3) or not (shCTL) in TLE3 The results presented are average of at least three independent experiments (Student's t-test * = P < 0.05; ** = P < 0.01).