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. 2014 Sep 23;42(18):11363–11382. doi: 10.1093/nar/gku827

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Dipyridyl (DP)-inducible CBP peaks are often near gene promoters and contain canonical hypoxia responsive elements (HREs), but are not reliable predictors of DP-inducible expression. (A) Location of DP-inducible CBP peaks relative to nearest gene TSS. (B and C) Distribution of DP-inducible CBP peaks located within 100 kb (B) or 1 kb (C) of the nearest gene (TSS). (D and E) Location of RCGTG HREs within 300 bases surrounding DP-inducible CBP peak summits including all HREs in the peak sequence (D) or only the centermost HRE in the peak (E). (F) Percentage of peaks containing RCGTG HREs broken down by distance from nearest TSS. (G) DP-inducibility of genes with a DP-inducible CBP peak within 2.5 kb of their TSS. WT DP gene expression shown as a percentage change from the uninduced (EtOH vehicle) WT gene expression. Percentages above the bars indicate the fraction of the 952 genes falling into each category.