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. 2014 Sep 16;42(18):11408–11418. doi: 10.1093/nar/gku834

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Complementation analysis with Arabidopsis AP endonucleases in AP endonuclease-deficient E. coli. Serial dilution assay to measure the cytotoxicity of DME expression in AP endonuclease-deficient RPC501 (xth- nfo-) strains with increasing amounts of IPTG (0–125 μM). The growth rate of RPC501 decreased as DME expression increased due to excessive 5mC excision. Expression of APE1L or ARP helped RPC501 strains to maintain cell growth by decreasing DME-induced cytotoxicity. APE2 expression did not restore normal growth rates.