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. 2014 Sep 22;42(18):11419–11432. doi: 10.1093/nar/gku842

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — A genetic screen for non-essential genes required for telomeric heterochromatin silencing in S. pombe. (A) Schematic diagram of the Tel::ura4⁺-natMX6 reporter. (B) Workflow to introduce TEL::ura4⁺ into the deletion library. (C) A representative image of cells grown on medium without uracil (-ura). Box indicates the position of tls1-1. (D) List of identified mutants affecting telomeric silencing. Hit colonies were assigned scores between 1 and 3, as indicated, 0 indicates background growth. (E) Schematic diagram of Tls1, the position of HEP59 domain was indicated. Shaded box indicates region deleted in tls1-1.