Table III.
Biodistribution of 64Cu-ALCAM-3L-amide-DOTA-cDb and 64Cu-ALCAM-3L-thioether-DOTA-cDb at 4 h post-injection of female nude mice bearing ALCAM-positive LS174T and ALCAM-negative C6 xenografts
| % ID/g ± SD |
|||
|---|---|---|---|
| Organ | amide-DOTA (n = 4) | Thioether-DOTA (n = 4) | P |
| Blood | 0.97 ± 0.11 | 1.4 ± 0.15 | <0.01 |
| LS174T (+) | 1.4 ± 0.15 | 2.6 ± 0.53* | <0.01 |
| C6 (−) | 0.99 ± 0.06 | 1.4 ± 0.06 | <0.0001 |
| Spleen | 3.8 ± 0.38 | 2.6 ± 0.19 | <0.005 |
| Stomach | 1.5 ± 0.27 | 4.0 ± 0.29 | <0.0001 |
| Intestines | 2.0 ± 0.16 | 4.3 ± 0.04 | <0.0001 |
| Liver | 36 ± 2.9 | 20. ± 2.5 | <0.0005 |
| Kidneys | 51 ± 5.7 | 95 ± 9.5 | <0.0005 |
| Heart | 1.2 ± 0.11 | 1.4 ± 0.09 | <0.05 |
| Lungs | 2.2 ± 0.20 | 3.7 ± 0.35 | <0.0005 |
| Muscle | 0.19 ± 0.02 | 0.24 ± 0.03 | 0.054 |
| Carcass | 0.61 ± 0.04 | 0.78 ± 0.03 | <0.0005 |
*n = 3, P-values for LS174T versus C6 for amide-DOTA and thioether-DOTA are <0.005 and <0.01, respectively.