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Intrastriatal injection of the AAV2/1-C4 scFv construct does not accelerate the pathogenic weight loss in HDR6/1 transgenic mice
| Treatment | Weight loss age of onset (mean week ± SE) | Percentage of wild-type body weight at 23 weeks | Percent dying by 25 weeks |
|---|---|---|---|
| HD sham females (n = 12) | 19.8 ± 0.5 | 90.4 ± 1.2 | 27.8 |
| HD-C4 females (n = 7) | 19.3 ± 0.8 | 88.1 ± 1.4 | 14.3 |
| HD sham males (n = 10) | 16.2 ± 0.8 | 64.2 ± 0.9 | 50 |
| HD-C4 males (n = 7) | 16.1 ± 0.1 | 64.2 ± 1.3 | 0 |
