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. 2014 Oct 9;8:112. doi: 10.3389/fnana.2014.00112

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Copyright © 2014 Wang, Zhang, Feng, Meng, Wu, Wang, Li, Zhang, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the proposed NT-NTR2 system in the PAG-RVM-SDH pathway. The efferent NT-expressing axon terminals from the PAG synapse on spinally projecting RVM neurons. The NT-expressing nerve fibers from the PAG may primarily synapse on NTergic neurons in the RVM that display NTR2-immunopositive staining, which, in turn, project to the SDH. In addition, some of the NTR2-IR neurons, but relatively fewer than the NT-IR neurons, express 5-HT. Approximately one-third of these NTR2-IR neurons appear to utilize both NT and 5-HT as their neurotransmitters. Thus, NT and 5-HT may be co-released in the SDH to modulate nociceptive transmission.