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. 2014 Oct 9;8:197. doi: 10.3389/fnsys.2014.00197

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Copyright © 2014 Ordek, Proddutur, Santhakumar, Pfister and Sahin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Purkinje cell degeneration at mild and moderate levels of severity of cerebellar injury (15 psi and 25 psi). (A–C) Representative confocal images show CalbindinD28k labeled PCs (A) and the absence of FluoroJade C staining (B) in the same section from a naïve rat (D–F). Images of a section from a rat 1 week after mild injury (15 psi) shows CalbindinD28k positive Purkinje cells (D) and the presence of a few FluoroJade C labeled cellular profiles (arrowheads in E). Merged image (F) shows that CalbindinD28k positive Purkinje cells are co-labeled with FluoroJade C (arrowheads) (G–I). Representative section from a rat 1 week after moderate injury (25 psi) shows CalbindinD28k positive Purkinje cells (G) and extensive cellular (arrowheads) and axonal (asterisk) FluoroJade C labeling (H). Merged image (I) shows numerous CalbindinD28k positive PCs labeled with FluoroJade C (arrowheads). Scale bar: 100 µm.