Table 1.
Epidemiological, Histological, and Clinical Data of Patients With FCDTCs Included in the Study
| Total | PTC | FTC | PDTC | ATC | |
|---|---|---|---|---|---|
| Total number | 469 | 332 | 70 | 31 | 36 |
| Age at diagnosis, y, n | 469 | 332 | 70 | 31 | 36 |
| Mean, y | 48.2 ± 16.9 | 44.8 ± 15.6 | 51.8 ± 16.4 | 53.2 ± 18.4 | 68.7 ± 10.4 |
| <45 | 211 (45.0) | 178 (53.6) | 23 (32.9) | 8 (25.8) | 2 (5.6) |
| ≥45 | 258 (55.0) | 154 (46.4) | 47 (67.1) | 23 (74.2) | 34 (94.4) |
| Gender, n | 459 | 327 | 68 | 29 | 35 |
| Female | 342 (74.5) | 254 (77.7) | 50 (73.5) | 16 (55.2) | 22 (62.9) |
| Male | 117 (25.5) | 73 (22.3) | 18 (26.5) | 13 (44.8) | 13 (37.1) |
| Tumor size, cm, n | 418 | 315 | 61 | 26 | 16 |
| <2a | 151 (36.1) | 142 (45.0) | 7 (11.5) | 2 (7.7) | 0 |
| 2–4 | 161 (38.5) | 129 (41.0) | 23 (37.7) | 7 (26.9) | 2 (12.5) |
| >4 | 106 (25.4) | 44 (14.0) | 31 (50.8) | 17 (65.4) | 14 (87.5) |
| Extrathyroidal extension, n | 373 | 268 | 49 | 20 | 36 |
| Present | 231 (61.9) | 176 (65.7) | 8 (16.3) | 12 (60.0) | 35 (97.2) |
| Vascular invasion, n | 325 | 257 | 53 | 8 | 7 |
| Present | 157 (48.3) | 103 (40.1) | 39 (73.6) | 8 (100.0) | 7 (100.0) |
| Lymph node metastasis, n | 391 | 298 | 47 | 24 | 22 |
| Present | 234 (59.8) | 202 (67.8) | 8 (17.0) | 14 (58.3) | 10 (45.5) |
| Distant metastasis, n | 337 | 263 | 31 | 20 | 23 |
| Present | 76 (22.6) | 36 (13.7) | 8 (25.8) | 14 (70.0) | 18 (78.3) |
| Stage (sixth UICC/AJCC), n | 310 | 225 | 29 | 20 | 36 |
| I | 134 (43.2) | 124 (55.1) | 8 (27.6) | 2 (10.0) | 0 |
| II | 36 (11.6) | 25 (11.1) | 8 (27.6) | 3 (15.0) | 0 |
| III | 45 (14.5) | 36 (16.0) | 5 (17.2) | 4 (20.0) | 0 |
| IV | 95 (30.7) | 40 (17.8) | 8 (27.6) | 11 (55.0) | 36 (100.0) |
| TERT promoter, n | 469 | 332 | 70 | 31 | 36 |
| Wild-type | 411 (87.6) | 307 (92.5) | 58 (82.9) | 22 (71.0) | 24 (66.7) |
| Mutation | 58 (12.4) | 25 (7.5) | 12 (17.1) | 9 (29.0) | 12 (33.3) |
Abbreviations: n, number of patients with available data for each feature; UICC, Union for International Cancer Control. Numbers in parentheses represent percentages within each category.
a
Number of microcarcinomas (≤1.0 cm): total, 47 (11.2%); PTC, 43 (13.7%); FTC, 4 (6.6%); PDTC, 0, ATC, 0.