Figure 1.

[¹¹C]6: a translational PET imaging probe. We have developed a potent HDAC imaging agent, termed [¹¹C]6, incorporating three key structural features to create a versatile and translational probe for visualizing HDAC expression in vivo. Intravenous injection of trace amounts of [¹¹C]6 (nanogram scale) in baboon and imaging by PET-MR demonstrates quantifiable uptake in the brain and in diverse peripheral organs. This illustrates the potential for [¹¹C]6 as a broadly applicable tool in evaluating HDAC density in humans.