Figure 2.

Kinetic modeling results with [¹¹C]6 in baboon brain. (A) The total volume of distribution (V_T) images from one representative animal show robust differences in radiotracer uptake at baseline and after blocking (0.5 mg/kg iv, 10 min pretreatment); (B) Two independent baseline-blocking studies were used to resolve quantitative V_T data which show that pretreatment with unlabeled 6 (0.5 or 1.0 mg/kg) dose-dependently blocks tracer uptake in different baboon brain regions. WB: whole brain; CB: cerebellum; M1: primary motor cortex ; PU: putamen; TH: thalamus; V1: primary visual cortex ; CA: caudate; WM: white matter.