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Superimposition of the X-ray structure of the etoposide/TopoIIβ complex (orange; PDB ID: 3QX3) on the X-ray structure of podophyllotoxin/tubulin complex (green; PDB ID: 1SA1) by fitting the A–D rings of the ligands. The yellow circle highlights the position of the fitted ligands. Proteins are displayed as ribbons, ligands are displayed as CPK. DNA is omitted, for clarity of presentation.
