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Potential modalities to be used as a combinatorial approach for castration-resistant prostate cancer. Reproduced with permission from Galsky MD et al.24 CYP17 indicates a cytochrome p450 complex involved in adrenal steroidal synthesis; Met RTK, Met receptor tyrosine kinase; VEGFR2, vascular endothelial growth factor receptor 2; RANKL, receptor activator of nuclear factor k-B ligand; RANK, receptor activator of nuclear factor k-B.
