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. Author manuscript; available in PMC: 2014 Oct 9.
Published in final edited form as: Hear Res. 2012 Nov 27;295:100–113. doi: 10.1016/j.heares.2012.11.016

Figure 12.

Figure 12

Infusion of SS (20 μl, 2.8 mM) into LA while recording from AC pre- and post-treatment. (A) Mean (±SEM, n=18) AC LFP input/output function to noise bursts obtained pre- and 2 h post-SS. Note large increase in LFP amplitude without threshold shift. (B-C) Matrix of peristimulus time histograms (PSTHs) obtained with tone bursts presented at 10 different frequencies (x-axis) at 6 intensities ranging from 0 to 100 dB SPL (y-axis). PSTH in each square shows the firing rate as a function of time (5 ms bin width, 500 ms total duration) to the 50 ms tone burst. Dashed blue line in panel B outlines FRF of the AC multiunit cluster prior to SS treatment; dashed red line in panel C outlines FRF of the multiunit cluster 2 h after infusing SS into the LA (blue dashed line from panel B also shown in panel C). Red horizontal arrow in panel C shows expansion of FRF towards the high frequencies. (D) Mean (±SEM) tuning curve of 3 (out of 16) multiunit clusters showing expansion of response area of low-frequency neurons towards the middle frequencies after SS infusion; response area shift towards the tinnitus pitch.