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. Author manuscript; available in PMC: 2014 Oct 9.
Published in final edited form as: Hear Res. 2012 Nov 27;295:100–113. doi: 10.1016/j.heares.2012.11.016

Figure 3.

Figure 3

Mean change (±SEM) in DPOAE amplitude after repeated salicylate injections. Sprague-Dawley rats (n=8) were injected with 300 mg/kg/d of salicylate for 4 days in period 1 and for 4 days in period 2. During period 1 and period 2, DPOAE were measured on each day of injection (open squares) and again after 2 days of rest (red filled triangles) and finally 70 day later. DPOAE measured at 3 frequencies (F2 = 8, 12, and 16 kHz) and at L1 = 60 dB SPL). Measurement made 2 h after each injection period (squares), 24 h after each rebound/rest period (red triangle) and at 70 days (dark red circle). Note decline in DPOAE amplitude during daily salicylate treatment and rebound in DPOAE amplitude after 2-day rest intervals and at 70 days.