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. Author manuscript; available in PMC: 2014 Oct 9.
Published in final edited form as: Hear Res. 2012 Nov 27;295:100–113. doi: 10.1016/j.heares.2012.11.016

Figure 4.

Figure 4

(A-C) Mean (±SEM, n=5) CAP input/output function obtained pre- and 2 h post-SS (300 mg/kg) at 8, 16 and 40 kHz. Dashed line represents a linear relationship between log CAP amplitude and stimulus level in dB SPL. Post-SS CAP input/output functions shifted approximately 30 dB to the right at low intensities at 8 and 40 kHz and about 20 dB to the right at 16 kHz. Post-SS input/output functions linear or nearly linear at 40 and 8 kHz respectively; 16 kHz input/output function retains its nonlinearity. Residual nonlinear amplification shown by the horizontal blue arrows; cochlear amplification retained at 16 kHz, but lost or greatly reduced at 40 and 8 kHz respectively. (D-E) The permanent effects of repeated salicylate treatments (200 mg/kg/day, 5 days/week for 3 weeks) on mean (±SEM, n=6) CAP amplitude. Note parallel shift to the right of CAP-I/O function (D) and a frequency-dependent CAP amplitude reduction at 70 dB SPL (E) with less impairment in the middle frequency region.