Table 3.
New SNP | Chr | Positiona | Gene | ORb | Pb | Conditional ORc | Conditional Pc | Established SNP | r2,d | ORe | Pe | Conditonal ORf | Conditional Pf |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs2736098 | 5p15.33 | 1,294,086 | TERT, CLPTM1L | 0.80 (0.74–0.86) | 1.42 × 10−9 | 0.88 (0.80–0.95) | 2.44 × 10−3 | rs401681 / rs31490 | 0.22 | 0.83 (0.79–0.88) | 1.97 × 10−11 | 0.86 (0.81–0.92) | 7.55 × 10−6 |
rs4962153 | 9q34.2 | 136,323,754 | ADAMTS13, ABO | 1.20 (1.10–1.30) | 1.97 × 10−5 | 1.05 (0.96–1.16) | 0.28 | rs505902 / rs687289 | 0.17 | 1.27 (1.20–1.35) | 1.64 × 10−16 | 1.25 (1.18–1.33) | 6.28 × 10−12 |
Position of SNP in NCBI genome build 37 (Hg19).
Per-allele ORs for the minor allele and P values for the new SNP from the unconditional meta-analysis of Stage 1 and Stage 2.
Per-allele ORs for the minor allele and P values for the new SNP from the conditional meta-analysis.
r2 LD values between the new SNP and the established SNP at the locus based on 1000 Genomes Project CEU data.
Per-allele ORs for the minor allele and P values for the established SNP from the unconditional meta-analysis of Stage 1 and Stage 2.
Per-allele ORs for the minor allele and P values for the established SNP from the conditional meta-analysis.
Chr: chromosome.