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. Author manuscript; available in PMC: 2014 Oct 9.
Published in final edited form as: Psychopharmacology (Berl). 2013 Apr 25;229(2):253–265. doi: 10.1007/s00213-013-3106-9

Figure 4.

Figure 4

Effects of fenobam sulfate on sucrose-induced reinstatement of reward-seeking behavior and cocaine-primed reinstatement of drug-seeking behavior. (a) Two groups of animals (vehicle and 30 mg/kg, n = 6; vehicle and 60 mg/kg, n = 5) were trained to self-administer sucrose and then sucrose-taking/-seeking behavior was extinguished. Pretreatment with 60 mg/kg fenobam sulfate significantly inhibited reinstatement of extinguished sucrose-seeking behavior following non-contingent sucrose delivery. (b) Three groups of animals (vehicle, n = 10; 30 mg/kg fenobam sulfate, n = 9; 60 mg/kg fenobam sulfate, n = 9) were trained to self-administer cocaine and then cocaine-taking/-seeking behavior was extinguished. Pretreatment with fenobam sulfate (0, 30 or 60 mg/kg, p.o.) dose-dependently inhibited cocaine-induced reinstatement of extinguished drug-seeking behavior in rats. * p < 0.05, ** p < 0.01, *** p < 0.001, compared to vehicle.