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Two possible models describing PCNA-mediated Okazaki fragment maturation. (Upper) A dynamic model in which Pol δ, FEN1, and Lig1 are bound and released from PCNA in a sequential manner. (Lower) The toolbelt model in which the three enzymes are simultaneously bound to PCNA using all available PCNA binding sites. The red segments represent the RNA primers; glowing circles represent enzymes currently active on the substrate.
