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. 2014 Sep 15;111(39):14289–14294. doi: 10.1073/pnas.1407640111

Fig. 3.

Fig. 3.

Enhanced energy expenditure and thermogenic function in aging Foxa3-null mice. (A) Oxygen consumption at room temperature (24 °C) of 14-mo-old (14m) WT and Foxa3-null (Foxa3 KO) mice. (B) Oxygen consumption in differentiated BAT and iWAT SVF cells from 14-mo-old WT and Foxa3-null mice under basal (Basal) or uncoupled conditions, using oligomycin (1 µM) (Uncoupled), or maximal oxidative capacity with FCCP (1 µM) (Max). (C) Body temperatures of 14-mo-old WT and Foxa3-null mice exposed to cold (4 °C) (n = 6). (D) Representative infrared images of 14-mo-old WT and Foxa3-null mice before and after cold exposure. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 compared with controls.