Fig. 5.

Foxa3 levels are increased in BAT and iWAT of aging mice, and levels of PGC1α and its targets are decreased. (A) Relative Foxa3 expression levels in BAT, iWAT, eWAT, gastrocnemius muscle (GAS), and liver (LIV) in 2-mo-old (2m) and 14-mo-old (14m) mice. The levels of Foxa3 expression in livers of 2-mo-old mice served as a reference. (B and C) mRNA levels of Pgc1α, Ucp1, and mitochondrial genes in BAT (B) and iWAT (C) of 2-mo-old and 14-mo-old mice. n = 6 per group. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 compared with controls.