Fig. 1.

Effect of Bmal1 deletion on wheel running activity. (A) Representative activity records of individual Bmal1^+/+, Bmal1^−/−, Bmal1^fx/fx, and SF1-Bmal1^−/− females are presented in double-plotted format. The bar above shows the light-dark cycle. DD, constant darkness; LD, light-dark. Gray shading indicates constant darkness in the actograms. (B–E) Effects of genotype on free running period (B), amplitude of circadian rhythm (C), and activity level in LD (D) and DD (E). *P < 0.05, by one-way ANOVA. Genotypes are indicated at the bottom of B–E.