Table 3. Exploratory Analyses (only resected patients included).

Outcome
	Cavitation (N=7)	No cavitation (N=34)	p-value
Downstaged	5 (71%)	14 (41%)
Not downstaged	2 (29%)	20 (59%)	0.22
Nodal down-staged	5 (83%)	12 (46%)
Not downstaged	1 (17%)	14 (54%)	0.18
Path response ≥90%	4 (57%)	7 (21%)
<90%	3 (43%)	27 (79%)	0.069
3-yr RFS all	63%	53%	0.43
3-yr RFS IIIA	57%	39%	0.32
3-yr OS all	60%	60%	0.83
3-yr OS IIIA	57%	44%	0.48
	KRAS-mutant (N=10)	KRAS wild-type (N=31)
Downstaged	5 (50%)	14 (45%)
Not downstaged	5 (50%)	17 (55%)	1.0
Nodal down-staged	5 (63%)	12 (50%)
Not downstaged	3 (37%)	12 (50%)	0.69
Path response ≥90%	0 (0%)	11 (35%)
<90%	10 (100%)	20 (65%)	0.039
3-yr RFS all	35%	65%	0.14
3-yr RFS IIIA	17%	56%	0.096
3-yr OS all	33%	72%	0.036
3-yr OS IIIA	17%	61%	0.068