Table 4.
Univariate Analysis of the Clinical Factors Influencing the Efficacy of 14-day hybrid Therapy
| Principle parameter | No of patients | Eradication rate | P value |
|---|---|---|---|
| Age | 0.55 | ||
| < 60 y | 74 | 98.6% (73/74) | |
| ≥ 60 y | 43 | 95.3% (41/43) | |
| Sex | 1.00 | ||
| Female | 59 | 96.6% (57/59) | |
| Male | 58 | 98.3% (57/58) | |
| Smoking | 1.00 | ||
| (−) | 98 | 96.9% (95/98) | |
| (+) | 19 | 100.0% (19/19) | |
| Alcohol consumption | 1.00 | ||
| (−) | 112 | 97.3% (109/112) | |
| (+) | 5 | 100.0% (5/5) | |
| Ingestion of coffee | 1.00 | ||
| (−) | 91 | 96.7% (88/91) | |
| (+) | 26 | 100.0% (26/26) | |
| Ingestion of tea | 0.28 | ||
| (−) | 71 | 96% (68/71) | |
| (+) | 46 | 100.0% (46/46) | |
| NSAID user | 1.00 | ||
| (−) | 110 | 97.3% (107/110) | |
| (+) | 7 | 100.0% | |
| Underlying diseases | 0.18 | ||
| (−) | 85 | 98.8% (84/85) | |
| (+) | 32 | 93.8% (30/32) | |
| Gastroduodenal diseases | 1.00 | ||
| Non-ulcer dyspepsia | 33 | 97.0% (32/33) | |
| Peptic ulcer | 84 | 97.6% (82/84) | |
| Adverse event | 0.38 | ||
| (−) | 100 | 98.0% (98/100) | |
| (+) | 17 | 94.1% (16/17) | |
| Compliance | 1.00 | ||
| Good | 111 | 97.3% (88/111) | |
| Poor | 6 | 100.0% (6/6) | |
| Antibiotic resistance | |||
| Clarithromycin resistance | — | ||
| susceptible | 53 | 100.0% (53/53) | |
| resistant | 4 | 100.0% (4/4) | |
| Amoxicillin | — | ||
| susceptible | 56 | 100.0% (56/56) | |
| resistant | 1 | 100.0% (1/1) | |
| Metronidazole resistance | — | ||
| susceptible | 25 | 100.0% (25/25) | |
| resistant | 32 | 100.0% (32/32) | |
| Presence of any resistant strain | — | ||
| (−) | 25 | 100.0% (25/25) | |
| (+) | 32 | 100.0% (32/32) | |
| Dual resistance | — | ||
| (−) | 53 | 100.0% (53/53) | |
| (+) | 4 | 100.0% (4/4) | |
| Triple resistance | — | ||
| (−) | 57 | 100.0% (57/57) | |
| (+) | 0 | — | |
a
Fifty seven strains were isolated.