TABLE I.

Names, abbreviations, and structure of transductionally and transcriptionally targeted adenoviruses used in this study

Targeting strategy	Virus name	Abbreviation	Description	Reference
Wild type (nontargeted)	Adenovirus serotype 5	Ad5-CMV- luc	Encodes Ad-5 fiber with cytomegalovirus (CMV) promoter driving luciferase (luc) transgene expression	21
Transductionally targeted (fiber- modified viruses)	Adenovirus- RGD	Ad5-RGD- luc	Integrin-binding peptide (arginine- glycine-aspartate) is attached to the adenovirus fiber HI loop to expand tropism to integrin expressing cells	15
	Adenovirus sigma	Ad-sigma-luc	Encode the wild type Ad5 fibers and the sigma-1 protein which is a reovirus attachment protein that can infect cells expressing sialic acid or junction adhesion molecule-1 (JAM-1)	22
	Adenovirus 5/3	Ad5/3-luc	Ad5 fiber knob has been replaced by that of Ad3 to redirect binding to the putative Ad3 receptors CD80, CD86, or CD46	23
Transcriptionally targeted (viruses with tissue- specific promoters)	Adenovirus- survivin	Ad-survivin- luc	Transgene expression is derived by survivin promoter	24
	Adenovirus- secretory leukocyte protease inhibitor	Ad-SLPI-luc	Transgene expression is derived by SLPI promoter	18
	Adenovirus- heparanase	Ad- heparanase luc	Transgene expression is derived by heparanase promoter	17

Ad, adenovirus; CMV, cytomegalovirus; luc, luciferase; RGD, integrin-binding peptide; SLPI, secretory leukocyte protease inhibitor.