TABLE I.
Targeting strategy |
Virus name | Abbreviation | Description | Reference |
---|---|---|---|---|
Wild type (nontargeted) |
Adenovirus serotype 5 |
Ad5-CMV- luc |
Encodes Ad-5 fiber with cytomegalovirus (CMV) promoter driving luciferase (luc) transgene expression |
21 |
Transductionally targeted (fiber- modified viruses) |
Adenovirus- RGD |
Ad5-RGD- luc |
Integrin-binding peptide (arginine- glycine-aspartate) is attached to the adenovirus fiber HI loop to expand tropism to integrin expressing cells |
15 |
Adenovirus sigma |
Ad-sigma-luc | Encode the wild type Ad5 fibers and the sigma-1 protein which is a reovirus attachment protein that can infect cells expressing sialic acid or junction adhesion molecule-1 (JAM-1) |
22 | |
Adenovirus 5/3 |
Ad5/3-luc | Ad5 fiber knob has been replaced by that of Ad3 to redirect binding to the putative Ad3 receptors CD80, CD86, or CD46 |
23 | |
Transcriptionally targeted (viruses with tissue- specific promoters) |
Adenovirus- survivin |
Ad-survivin- luc |
Transgene expression is derived by survivin promoter |
24 |
Adenovirus- secretory leukocyte protease inhibitor |
Ad-SLPI-luc | Transgene expression is derived by SLPI promoter |
18 | |
Adenovirus- heparanase |
Ad- heparanase luc |
Transgene expression is derived by heparanase promoter |
17 |
Ad, adenovirus; CMV, cytomegalovirus; luc, luciferase; RGD, integrin-binding peptide; SLPI, secretory leukocyte protease inhibitor.