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. Author manuscript; available in PMC: 2014 Oct 9.
Published in final edited form as: J Pharmacol Clin Toxicol. 2014;2(1):1017–1026.

Table 7.

Monte Carlo Simulations of Vancomycin Regimens in Children with Normal (Control) and Impaired (Case) Renal Functiona,b.

Dosing Regimen Parameter Control Case
45 mg/kg/day (15 mg/kg every 8 hr) Cmin, mcg/mL 9 (5–18) 19 (13–34)
AUC, mcg-hr/mL 429 (316–677) 691(544–1075)
60 mg/kg/day (15 mg/kg every 6 hr) Cmin, mcg/mL 14 (9–27) 28 (20–49)
AUC, mcg-hr/mL 572 (421–903) 922 (725–1434)
70 mg/kg/day (17.5 mg/kg every 6 hr) Cmin, mcg/mL 17 (10–32) 33 (24–57)
AUC, mcg-hr/mL 668 (491–1053) 1075 (846–1673)

Abbreviations: Cmin = minimum or trough concentration; AUC = Area-Under-Curve over 24 hr

a

Numbers represent median (interquartile range).

b

Using the paired t-test, the p-values for all Cmin and AUC between control and case groups were <0.001.