Table 7.
Dosing Regimen | Parameter | Control | Case |
---|---|---|---|
45 mg/kg/day (15 mg/kg every 8 hr) | Cmin, mcg/mL | 9 (5–18) | 19 (13–34) |
AUC, mcg-hr/mL | 429 (316–677) | 691(544–1075) | |
60 mg/kg/day (15 mg/kg every 6 hr) | Cmin, mcg/mL | 14 (9–27) | 28 (20–49) |
AUC, mcg-hr/mL | 572 (421–903) | 922 (725–1434) | |
70 mg/kg/day (17.5 mg/kg every 6 hr) | Cmin, mcg/mL | 17 (10–32) | 33 (24–57) |
AUC, mcg-hr/mL | 668 (491–1053) | 1075 (846–1673) |
Abbreviations: Cmin = minimum or trough concentration; AUC = Area-Under-Curve over 24 hr
Numbers represent median (interquartile range).
Using the paired t-test, the p-values for all Cmin and AUC between control and case groups were <0.001.