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Large genomic alterations in marrow CD34+ cells are detected in matched T cells of some patients with MDS. Array comparative genomic hybridization (aCGH) (A) and fluorescence in situ hybridization (FISH) (B) show deletions of chromosome 20 (1 and 3) as well as amplifications of chromosome 20 (2 and 4) in Patient 5, and trisomy 8 by aCGH (C) and FISH (D) in Patient 25. The red bar depicts the locus of the probe used for FISH.
