Table I.
Clinical, chromosomal and TCR rearrangement characteristics of 40 patients with MDS or MDS/MPN analyzed by array CGH for chromosomal changes in T cells..
| Patient number |
Age (years) |
Gender | Diagnosis | Karyotype | Origin of T cells |
Chromosomal abnormality present in T cells |
TRG@ rearrangement |
|---|---|---|---|---|---|---|---|
| 1 | 77 | F | 5q- syndrome | 46,XX, del5q | BM | No | ND |
| 2 | 86 | F | RA | 46,XX | BM | NA | ND |
| 3 | 78 | F | RA | 46,XX | PB | NA | Polyclonal |
| 4 | 78 | M | RA | 46,XY, del20q | BM | Yes | ND |
| 5 | 54 | M | MDS/MPN (RARS-T) | 46,XY, del20q | PB | Yes | Clonal |
| 6 | 78 | M | RA | 46,XY/45,X-Y | BM | NA | ND |
| 7 | 80 | M | RCMD | 46,XY | PB | NA | Clonal |
| 8 | 75 | F | RA | 46,XX | PB | NA | ND |
| 9 | 56 | M | RA | 46,XY | BM | NA | ND |
| 10 | 79 | M | RA | 46,XY | BM | NA | Polyclonal |
| 11 | 69 | F | RA | 46,XX | BM | NA | ND |
| 12 | 63 | M | MDS/MPN | 46,XY | BM | NA | ND |
| 13 | 49 | F | RA | 46,XX | BM | NA | Oligoclonal |
| 14 | 73 | F | RA | 46,X idicXq13 | PB | Yes | Clonal |
| 15 | 84 | M | RA | 45,X-Y | PB | NA | ND |
| 16 | 74 | M | RA | 45,X-Y, del7 | BM | No | ND |
| 17 | 53 | M | RA | 46,XY, del20q | PB | No | Polyclonal |
| 18 | 79 | M | RCMD | 46,XY, del7, +8 | BM | No | Oligoclonal |
| 19 | 83 | M | RARS | 46,XY | BM | NA | ND |
| 20 | 68 | F | RARS | 46,XX | BM | NA | ND |
| 21 | 81 | F | MDS/MPN (RARS-T) | 46,XX | BM | NA | ND |
| 22 | 81 | M | RAEB-1 | 46,XY | BM | NA | Polyclonal |
| 23 | 83 | M | RARS | 46,XY | NA | NA | ND |
| 24 | 60 | M | RARS | 46,XY | BM | NA | Oligoclonal |
| 25 | 81 | M | RARS | 46,XY, +8 | BM | Yes | ND |
| 26 | 33 | F | RARS | 46,XX | BM | NA | ND |
| 27 | 76 | M | RARS | 46,XY | BM | NA | Oligoclonal |
| 28 | 52 | M | RARS | 46,XY | BM | NA | ND |
| 29 | 71 | F | RA | NA | BM | NA | ND |
| 30 | 66 | M | RA | NA | PB | NA | ND |
| 31 | 60 | M | MDS-NOS | 46,XY | BM | NA | ND |
| 32 | 74 | M | RCMD-RS | 46,XY, del11q | BM | Yes | ND |
| 33 | 74 | M | RCMD-RS | 46,XY, del5q, +8 | BM | Yes | Oligoclonal |
| 34 | 61 | M | RAEB-1 | NA | BM | NA | ND |
| 35 | 66 | F | MDS/MPN | 46,XX | BM | NA | Polyclonal |
| 36 | 85 | M | MDS/MPN | 46,XY | BM | NA | ND |
| 37 | 66 | M | RARS | 46,XY, +8 | BM | Yes | Clonal |
| 38 | 68 | F | RARS | 46,X idicXq13 | BM | Yes | ND |
| 39 | 64 | M | MDS/MPN | NA | BM | Yes | ND |
| 40 | 82 | M | MDS-NOS | NA | BM | NA | ND |
F, female; M, male; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; NOS, not otherwise specified; RA, refractory anaemia; RARS(-T), refractory anaemia with ring sideroblasts (in transformation); RCMD(-RS), refractory cytopenia with multilineage dysplasia (with ring sideroblasts); RAEB-1, refractory anaemia with excess blasts, type 1; Del, deletion; Idic, isodicentric; NA, not applicable; PB, peripheral blood; BM, bone marrow; ND, not done.