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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Stroke. 2014 Feb 18;45(4):1012–1017. doi: 10.1161/STROKEAHA.113.004166

Table 2.

Regression models evaluating distinct signs of retinal microvascular disease, each, with MRI small vessel disease.

Incident Lacunes (OR**) WMP category (OR**) WMP volume (Beta***)
Unadjusted Adjusted* Unadjusted Adjusted* Unadjusted Adjusted*
Any retinopathy 2.16
(1.14,4.09) 		2.31
(1.10,4.86) 		1.46
(0.77,2.77)		 1.39
(0.65,2.95)		 3.42
(1.07,5.78) 		3.47
(1.00,5.93)
AV Nicking 1.94
(1.21,3.11) 		1.75
(1.04,1.14) 		1.73
(1.10,2.70) 		1.48
(0.88,2.48)		 3.57
(1.93,5.21) 		2.58
(0.24,0.51)
Focal Arteriolar
Narrowing		 2.00
(1.28,3.14) 		1.60
(0.98,2.62)		 0.98
(0.61,1.57)		 0.87
(0.51,1.48)		 2.46
(0.89,4.03)		 1.45
(−0.13,3.03)
CRAE 0.99
(0.96,1.01)		 0.99
(0.96,1.02)		 1.006
(0.98,1.03)		 1.00
(0.97,1.03)		 0.02
(−0.09,0.12)		 0.03
(−0.09,0.15)
CRVE 1.00
(0.97,1.02)		 1.00
(0.97,1.04)		 1.006
(0.98,1.03)		 1.02
(0.98,1.05)		 0.02
(−0.09,0.13)		 0.05
(−0.07,0.18)
Microaneurysms 1.55
(0.65,3.73)		 1.61
(0.58,4.47)		 0.99
(0.40,2.49)		 0.81
(0.27,2.43)		 2.55
(−0.56,5.65)		 2.16
(−1.18,5.51)
Retinal
Hemorrhage		 2.53
(1.05,6.08) 		2.46
(0.87,6.93)		 2.22
(0.95,5.15)		 1.93
(0.71,5.28)		 3.33
(0.03,6.63) 		3.27
(−0.14,6.69)
*

Adjusted for age, gender, race, study center, total and HDL cholesterol, BMI, pack-years, cumulative SBP, blood glucose, and presence of CHD.

**

Results for lacunes (incident) and categorical progression of WMP are odds ratios (OR) with 95% CI’s, since these were derived from logistic regressions.

***

Volume change in WMP results are beta coefficients from linear regressions (with 95% CI).