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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Aug 8;24(18):4477–4481. doi: 10.1016/j.bmcl.2014.07.089

Table 2.

Chemical yields of N-benzyl 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides (11) and their antiproliferative activities against DU-145 cells.

graphic file with name nihms626141u2.jpg
Compound R Yield, % GI50 (μM)a
11a graphic file with name nihms626141t21.jpg 44 1.6 ± 0.2
11b Bn 68 0.76 ± 0.09
11c Ph 67 1.9 ± 0.4
11d graphic file with name nihms626141t22.jpg 58 0.52 ± 0.05
11e graphic file with name nihms626141t23.jpg 32 11.2 ± 1.1
11f graphic file with name nihms626141t24.jpg 45 8.6 ± 0.4
11g graphic file with name nihms626141t25.jpg 51 12.3 ± 0.7
11h graphic file with name nihms626141t26.jpg 62 1.2 ± 0.05
11i graphic file with name nihms626141t27.jpg 73 Inactive
11j Me 46 Inactive
11k graphic file with name nihms626141t28.jpg 38 9.3 ± 0.4
11l graphic file with name nihms626141t29.jpg 67 2.9 ± 0.2
11m graphic file with name nihms626141t30.jpg 64 4.4 ± 0.4
a

The data shown are the means of three experiments ± standard deviation. Inactive - compounds showing <20% DU-145 growth inhibition at 50 μM.