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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Aug 8;24(18):4477–4481. doi: 10.1016/j.bmcl.2014.07.089

Table 3.

GI50 data (DU-145 cells) and structures of the SAR-merging ‘crossover’ compounds 12a-d.

graphic file with name nihms626141u3.jpg
Compound R1 R2 GI50, μMa
12a Bn graphic file with name nihms626141t31.jpg 0.12 ± 0.03
12b Bn graphic file with name nihms626141t32.jpg 0.95 ± 0.12
12c PhOCH2 graphic file with name nihms626141t31.jpg 1.7 ± 0.3
12d PhOCH2 graphic file with name nihms626141t32.jpg 2.8 ± 0.2
a

The data shown are the means of three experiments ± standard deviation.