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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Aug 8;24(18):4477–4481. doi: 10.1016/j.bmcl.2014.07.089

Table 4.

Inhibition of tubulin assembly activity (IC50) of some 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides.

graphic file with name nihms626141u4.jpg
Compound R1 R2 IC50, μM ± SD
1 4-ClC6H4 graphic file with name nihms626141t33.jpg 2.0 ± 0.08
1a 4-MeC6H4 graphic file with name nihms626141t33.jpg 2.3 ± 0.2
2 4-MeC6H4 3-MeOC6H4 3.0 ± 0.1
2a 4-ClC6H4 3-MeOC6H4 5.3 ± 0.5
8d 4-FC6H4 Bn 1.6 ± 0.1
11a 4-MeC6H4 Bn 1.1 ±0.02
11c Ph Bn 1.8 ± 0.1
11k 2-ClC6H4 Bn 2.6 ± 0.2